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Cotton candy inspired device easily spins nanofibers

26 May '10
4 min read

Parker's Disease Biophysics Group (DBG), which has extensive expertise in cardiac tissue engineering, also used the technology to form tissue engineering scaffolds, or artificial structures upon which tissue can form and grow. Heart tissue from rats was integrated and aligned with the nanofibers, and, as seen in past studies, formed beating muscle.

“I was visiting the Society of Laproscopic Surgeons a couple of years ago to look at the equipment demos and it dawned on me that we needed to develop techniques to miniaturize scaffold production so we could do it in vivo. Our finding is the first step,” explains Parker. “The initial testing suggests that our technique is incredibly versatile for both research and everyday applications. As rotary jet spinning does not require high voltage, it really brings nanofiber fabrication to everyone.”

The researchers expect to further refine the process for tissue engineering applications and to look for opportunities to exploit the advance in other textile applications. Badrossamay and Parker's co-authors include Holly Alice McIlwee a bioengineering graduate student at SEAS, and Josue A. Goss, the DBG laboratory manager who built the machine with Badrossamay.

The researchers acknowledge the support of the Nanoscale Science and Engineering Center (NSEC) at Harvard; the Materials Research Science and Engineering Center (MRSEC) at Harvard; and Harvard Center for Nanoscale Systems (CNS), and the Wyss Institute for Biologically Inspired Engineering at Harvard. The work was also funded in part by a National Science Foundation's (NSF) graduate research fellowship program.

Harvard School of Engineering and Applied Sciences (SEAS)

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