He has held a variety of senior general management roles including leadership of Nike's US and European businesses.
Perez joined Nike in December 2004 after a long career with S C Johnson, based in Racine, Wisconsin.
Perez said that he has great respect for the Nike brand, the company and the board.
Nike is an incredible organization with tremendous growth opportunities.
However, Phil and he weren't entirely aligned on some aspects of how to best lead the company's long-term growth.
It became obvious to that the long-term interests of the company would be best served by his resignation.
To discuss these changes with analysts and investors, the company will hold a conference call at 1 pm EST Jan 23.
NIKE Inc based in Beaverton, Oregon is the world's leading designer, marketer and distributor of authentic athletic footwear, apparel, equipment and accessories for a wide variety of sports and fitness activities.